In addition to finding and killing monsters, you must also complete numerous challenges that require specific resources that you can find on the board. You have to use logic and deduction to reason out where the resources you need are located. Ally yourselves with Sacagawea and the indigenous people of the area to help you on your quest.
The game comes with two chapters: Fauna and Flora. Each has new mechanisms, a different goal, and new components to give each chapter a different feel.